Tokyo Relife Clinic

Tokyo Relife Clinic is a premier regenerative medicine institution located in the upscale Ginza district of Tokyo, Japan. Founded with a singular vision — to be the world's first and most advanced facility integrating clinical medicine, in-house cell culture laboratory, and an academic research institute on a single campus — the clinic stands at the forefront of longevity medicine, anti-aging science, and regenerative therapy for international patients seeking treatments unavailable in their home countries. The clinic is led by Director Dr. Masaki Nakao, who graduated from St. Marianna University School of Medicine in 1997, completed a PhD in Medicine in 2009, and subsequently served as a Research Fellow at Massachusetts Eye and Ear Infirmary at Harvard Medical School. Her clinical expertise bridges ophthalmology, regenerative medicine, and anti-aging medicine, with a philosophy centered on evidence-based, highly personalized care. In 2026, she was joined by Chief Advisor Professor Hidekazu Yamada — former President of the Japan Society of Anti-Aging Medicine and Professor of Dermatology at Kinki University — who completed advanced research at the University of Vienna and the US National Institutes of Health (NIH). This leadership team positions Tokyo Relife as Japan's most scientifically rigorous regenerative medicine practice. The clinic's structural model is its most distinctive feature. Unlike conventional clinics that outsource cell culture to third-party facilities, Tokyo Relife operates its own on-site cell culture laboratory operating under strict Standard Operating Procedures (SOP). Every batch of cultured cells undergoes DNA-level quality certification using iScan (Illumina) genetic analysis prior to patient administration — a quality assurance protocol described as a first in Japan. The clinic has also implemented the world's first Epigenetic Clock Test system, which uses DNA methylation analysis to calculate a patient's biological age at the cellular level, measure the progression of cellular senescence, and objectively verify the effectiveness of regenerative treatments over time. Stem cell therapy using autologous adipose-derived stem cells (ADSCs) is the clinic's flagship offering. The process begins with a minor liposuction procedure to harvest a small amount of the patient's own fat tissue. Stem cells are extracted, cultured to reach the target quantity in the in-house laboratory, and then re-administered via intravenous infusion or targeted local injection. Because the treatment uses the patient's own cells, risks of allergic reactions and immune rejection are minimised. The therapy is offered for a wide range of conditions including age-related physical decline, chronic pain, joint disorders (knee osteoarthritis), neurological conditions (stroke, cognitive decline), diabetes and metabolic conditions, menopausal and andropausal symptoms, hair thinning, erectile dysfunction, and arteriosclerosis. Beyond stem cell therapy, Tokyo Relife offers a comprehensive longevity medicine programme designed around the philosophy of 'cellular rejuvenation.' This includes high-dose intravenous vitamin C infusions combined with multi-functional customisable IV protocols, epigenetic age testing as a baseline and follow-up measure, molecular nutrition optimisation, and a suite of anti-aging aesthetic treatments including Juvéderm Vista and Botox Vista administered by certified physicians. The clinic treats patients across three dedicated floors in a purpose-built luxury facility whose design prioritises privacy, calm, and a premium patient experience. In partnership with an endowed research chair at the University of Tokyo, the clinic maintains a research team with the explicit mandate of translating cutting-edge academic discoveries into clinical therapies at the fastest possible pace — from research to clinical practice and back again. This 'ultra-practical' research approach aims to give patients access to treatments at the frontier of what scientific evidence currently supports. For international patients, Tokyo Relife provides English-language consultations, comprehensive pre-treatment health assessments, and tailored treatment plans. The clinic's Ginza location is easily accessible from major Tokyo transport hubs and sits minutes from luxury hotels and international airlines. A full medical concierge service supports international patients from initial enquiry through to post-treatment follow-up.